ABC of Antithrombotic by Edited by Andrew D. Blann Edited by Gregory Y. H. Lip

By Edited by Andrew D. Blann Edited by Gregory Y. H. Lip

Urban health facility, Birmingham, united kingdom. Discusses the motives and effects of blood clots, how antithrombotic remedy works and its makes use of for sufferers. Addresses bleeding hazards, venous thromboembolism, atrial traumatic inflammation, peripheral vascular disorder, center failure, and anticoagulation. ample halftone and colour illustrations. Softcover.

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The European and North American guidelines have minor differences. The duration of antithrombotic therapy also varies according to a number of factors. Lifelong anticoagulant treatment is indicated for patients with mechanical valves and those with bioprosthetic valves or native valve disease with additional risk factors. 5 for three months. 5 for three months. 5 is used ‡Low dose aspirin is used by most centres in the United Kingdom Modification of anticoagulant treatment may be required in patients who have prosthetic valves and are undergoing non-cardiac surgical procedures, who are are pregnant, or who have resistance to oral anticoagulants.

These factors include age, smoking, hypertension, diabetes, hyperlipidaemia, type and severity of valve lesion, presence of atrial fibrillation, heart failure or low cardiac output, size of the left atrium (over 50 mm on echocardiography), previous thromboembolism, and abnormalities of the coagulation system including hepatic failure. Secondly, the type, number, and location of prostheses implanted must be considered. For example, mechanical prostheses are more thrombogenic than bioprostheses or homografts, and hence patients with mechanical valves require lifelong anticoagulant therapy.

Chest 2001;119:300–20S x Atkinson RP, DeLemos C. Acute ischemic stroke management. Thromb Res 2000;98:V97-111 x CAPRIE Steering Committee. A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-39 x CAST Collaborative Group. CAST: randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke. Lancet 1997;349:1641-9 x International Stroke Trials Collaborative Group. IST: a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke.

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