By Theodore Friedmann, Jay C. Dunlap, Stephen F. Goodwin
The publication constantly publishes very important stories of the broadest curiosity to geneticists and their colleagues in affiliated disciplines, seriously reading destiny directions.
1. Genetics and Pharmacology of durability: the line to Therapeutics for fit Aging
Jorge Iv?n Castillo-Quan, Kerri J. Kinghorn and Ivana Bjedov
2. MicroRNAs: instruments of Mechanistic Insights and organic Therapeutics Discovery for the infrequent Neurogenetic Syndrome Lesch-Nyhan sickness (LND)
3. Small RNAs in micro organism and Archaea: Who they're, What They Do, and the way They Do It
E. Gerhart H. Wagner and Pascale Romby
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For instance, all life span-extending interventions, DR, and down-regulation of IIS and mTOR signaling, result in induction of autophagy (Bjedov & Partridge, 2011). Autophagy ensures survival under starvation conditions as it recycles cellular material to provide energy for the cell. The evolutionary conservation of the machinery involved in autophagy is exquisite and therefore demonstrates the relevance of this process across taxa. , 2013). Amino acid sensing does not seem to require the TSC complex, as amino acid deprivation in cells lacking TSC2 still shows dephosphorylation of S6K, ribosomal protein S6 (downstream of S6K), the eukaryotic initiation factor 4E (eIF4E)-binding protein (4E-BP) and the elongation factor-2 kinase (EF-2K), all of which are downstream of mTORC1 and phosphorylated under conditions of mTORC1 activation (Smith, Finn, Tee, Browne, & Proud, 2005).
2009). , 2013). Considering this observation, two explanations have been considered. First, long-lived individuals and their families must show reduced prevalence of disease-susceptibility alleles, hence the lower incidence of disease. , 2013). The ﬁrst explanation seems very unlikely. , 2011). , 2014). , 2008). , 2014). The ε4 variant of APOE has also been consistently associated with late-onset Alzheimer’s disease and also with cardiovascular disease (Peila, Rodriguez, & Launer, 2002). Interestingly 44 Jorge Ivan Castillo-Quan et al.
Additionally other signaling kinases like GSK-3 can also modulate mTOR signaling. GSK-3 also phosphorylates TSC2, but in turn this phosphorylation activates the GAP activity of the complex, hence inhibiting signaling through mTOR. , 2006). Both Erk and GSK-3 can modulate mTOR independent of the TSC complex. , 2011). , 2011). , 2007). Given the central role of mTOR in the integration of multiple cellular inputs, its detailed and stratiﬁed interaction with other signaling pathways is not surprising.